The Massachusetts native, an official entrant in the race, will run the 111th Boston Marathon in April while aboard the International Space Station.
Although she will be running in place aboard the station, she will circle the globe at least twice as it orbits at more than five miles each second.
Williams, 41, who has been aboard the space station since December 2006, has trained for months on a treadmill mounted on a sophisticated system of shock absorbers and gyroscopes that prevent vibrations, a representative for the space agency said.
Her sister, Dina Pandya, will run the marathon in Boston on April 16 with another astronaut, Karen Nyberg.
Williams ran with Nyberg in the Houston Marathon in January 2006 when both qualified for the Boston race by finishing among the top 100 women.
Williams' run may not coincide with the actual race because of work and sleep schedules on the station. She had long been scheduled to be in space at the time of the Boston Marathon.
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